Influence of glucose concentration on blood optical properties in THz frequency range
doi:10.3788/CO.20181102.0182
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摘要:无创性血糖检测仍是糖尿病患者护理安全舒适的现实科学任务。本文研究了血糖光学特性与血糖浓度之间的相关性。用时域THz光谱研究了全血在0.3~0.5 THz频率范围内的透射谱。在注射胰岛素后的短时间内，由同一糖尿病患者产生了生物样品。得到了血液光学特性的频散特性。基于频散，给出了血糖浓度与折射率和介电常数的关系式。这项工作是复杂研究的一部分，重点是无创葡萄糖测量技术的发展。记录血糖水平与血液光学参数之间的依赖关系，使得将来可以使用反射光谱技术进行无创血糖水平检测。Abstract:Non-invasive blood glucose sensing is still actual scientific task for more safe and comfort diabetes care. This article shows correlation between blood optical properties and its glucose concentration. The transmission spectra of whole blood have been studied by the time-domain THz spectroscopy in the frequency range from 0.3 to 0.5 THz. Biosamples were produced from the same person with the diabetes mellitus during a short time period after the insulin injection have been used. Frequency dispersions of blood optical properties are obtained. Based on frequency dispersions, the dependences of blood glucose concentrations with the refractive index and permittivity are presented. This work is a part of the complex investigation, which focuses on the development of a non-invasive glucose measuring technique. Registering dependences between blood glucose level and blood optical parameters allows for using the reflective spectroscopy techniques in future for non-invasive blood glucose level sensing.
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Key words:
- spectroscopy/
- terahertz/
- glucose/
- diabetes mellitus
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Figure 1.Schematic diagram of the setup(FL-1:femtosecond laser based on potassium-yttrium tungstate crystal activated with ytterbium(Yb:KYW), generating femtosecond pulses; F1, 2:a set of teflon filters for IR wavelength range cutting off, BS:beamsplitter, DL:optical delay line, M1, 2, 3:mirrors, Sam:investigated sample, Wol.:Wollaston prism, CdTe:electro optical cadmium-telluric crystal, BD:balanced detector, LA:lock-in amplifier, PC:personal computer, GTP:Glan-Taylor prism, PM1, 2:parabolic mirrors, Ch:chopper, DAC:digital to analog converter, ADC:analog to digital converter
Figure 4.Dispersions of optical parameters of samples with different glucose concentrationcglucose: (a)the real part of refractive indexnreal(f); (b)the absorption coefficientα(f); (c)the real part of permittivityεreal(f); (d)the imaginary part of permittivityεimag(f)
Figure 5.Dependencies of glucose concentration with (a) the real part of refractive indexcglusoseand (b)with the real part of permittivitycglucose(εreal) at different frequencies
Table 1.The list of the glucose concentrations of samples used in experiment
Sample No. mmol/L mg/dL 1 3.0 54.0 2 3.8 68.4 3 6.2 111.6 4 9.2 165.6 5 11.0 198.0 6 14.9 268.2 7 18.0 324.0 8 19.0 342.0 
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