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特种芯光纤光镊技术研究进展

李红,朱应鑫,周雅妮,王海波,董明利,祝连庆

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李红, 朱应鑫, 周雅妮, 王海波, 董明利, 祝连庆. 特种芯光纤光镊技术研究进展[J]. , 2023, 16(6): 1293-1304. doi: 10.37188/CO.2023-0016
引用本文: 李红, 朱应鑫, 周雅妮, 王海波, 董明利, 祝连庆. 特种芯光纤光镊技术研究进展[J]. , 2023, 16(6): 1293-1304.doi:10.37188/CO.2023-0016
LI Hong, ZHU Ying-xin, ZHOU Ya-ni, WANG Hai-bo, DONG Ming-li, ZHU Lian-qing. Advances in optical fiber tweezer technology based on hetero-core fiber[J]. Chinese Optics, 2023, 16(6): 1293-1304. doi: 10.37188/CO.2023-0016
Citation: LI Hong, ZHU Ying-xin, ZHOU Ya-ni, WANG Hai-bo, DONG Ming-li, ZHU Lian-qing. Advances in optical fiber tweezer technology based on hetero-core fiber[J].Chinese Optics, 2023, 16(6): 1293-1304.doi:10.37188/CO.2023-0016

特种芯光纤光镊技术研究进展

doi:10.37188/CO.2023-0016
基金项目:国家自然科学基金(No. 61903042);北京市自然基金(No. 4202027);北京信息科技大学2022年大学生创新创业训练计划项目(No. S202211232012)
详细信息
    作者简介:

    李 红(1985—),女,河北唐山人,博士,硕士生导师,2016年于合肥工业大学获得博士学位,主要研究方向为光纤传感技术、仪器科学与精密测量等。E-mail:lihong@bistu.edu.cn

    朱应鑫(1998—),男,山东济南人,硕士研究生,2021年于青岛理工大学获得学士学位,主要研究方向为光纤光镊技术。E-mail:zhuyingxin1998@163.com

  • 中图分类号:Q631

Advances in optical fiber tweezer technology based on hetero-core fiber

Funds:Supported by National Natural Science Foundation of China (No. 61903042); Beijing Natural Science Foundation (No. 4202027); 2022 Undergraduate Innovation and Entrepreneurship Training Program of BISTU (No. S202211232012)
More Information
  • 摘要:

    光纤光镊具有结构简单、操作灵活、尺寸小的特点,在生化分析、生命科学等领域有广泛应用。特殊纤芯结构的光纤探针在近场倏逝波光阱力、纤芯光束耦合传输、微流控技术交叉协同应用等方面具有天然优势,能实现细胞、亚细胞级微粒收集、输运等功能,可以显著提升微粒的三维捕获能力以及动态操纵水平。本文综述了不同纤芯结构光纤光镊的结构特点与应用技术研究进展,对特种芯光纤光镊系统中探针制备、 光源、耦合方式等关键技术进行了梳理和对比,总结与展望了不同结构特种芯光纤在光纤光镊中的作用与发展。

  • 图 1常见特种芯光纤横截面示意图

    Figure 1.Cross section diagram of common hetero-core fibers

    图 2特种芯光纤光镊系统组成

    Figure 2.Hetero-core optical fiber tweezers system

    图 3特种芯光纤探针耦合结构示意图。(a)单模光纤直接熔接探针中一芯,耦合后双芯通光;(b)单模光纤直接熔接双芯探针,拉锥熔接区域耦合通光[22];(c)单模光纤错芯熔接多模探针,干涉产生不对称类贝塞尔光束[27];(d)单模错位熔接中空环形芯光纤探针[13];(e)单模光纤纳米探针耦合中空光子晶体光纤[28]

    Figure 3.Schematic diagrams of hetero-core optical fiber probe coupling structures. (a) Single-mode fiber direct fusion probe in one core, and the two-core light is achieved after coupling; (b) single-mode fiber direct fusion dual-core probe, taper welding area coupled through light[22]; (c) single-mode fiber core-offset splicing multimode probe to generate asymmetric Bessel-like beam by interference[27];(d) single-mode dislocation splicing hollow ring core fiber probe[13]; (e) single-mode fiber nanoprobe coupled hollow photonic crystal fiber[28]

    图 4基于多芯结构光纤光镊探针结构。(a)等离子体锥形双芯光纤光镊横截面[19];(b)三芯光学微手结构与涡旋光场场强分布[38];(c)四芯光纤端面显微镜照片,光纤直径150 μm对角纤芯间距65 μm;光纤镊的截面设计;两收敛光束从加工对角纤芯传播的三维示意图,收敛区域球体代表一个被捕获细胞[15]

    Figure 4.Probe structure based on multi-core fiber optical tweezers. (a) Cross section of plasma tapered dual-core optical fiber tweezers[19]; (b) three-core optical micro-hand structure and vortex field intensity distribution[38]; (c) Four-core fiber end face microscope photo, fiber diameter is 150 μm and diagonal core spacing is 65 μm; design of fiber tweezers' cross section; a three-dimensional diagram of two convergent beams propagating from the processing diagonal fiber core. The sphere in the convergent region represents a captured cell[15]

    图 5ACF光纤光镊结构与工作示意图。(a)鸟喙形环形芯光纤探针及微粒受力仿真示意图[44];(b)中空环形芯光纤光镊[13];(c)环形芯光纤截面图像,带二氧化硅微球的环形芯光纤探头图像,暗场光漏斗原理图[14];(d)基于同轴环形双波导的尺寸测量干涉方法示意图,M1为纤维端面,M2为被困微球左侧, MS为微球[45]

    Figure 5.Structure and operating diagram of optical fiber tweezers with ring core structure.(a) Beak-shaped ring-core optic fiber probe and particle force simulation diagram[44]; (b) hollow ring core optical fiber tweezers[13]; (c) cross-section image of annular core fiber, image of annular core fiber probe with silica microspheres, and schematic diagram of dark field optical funnel[14]; (d) schematic diagram of size measurement interference method based on coaxial ring double waveguide.M1is the fiber end face,M2is the left side of the trapped microsphere, and MS is the microsphere[45]

    图 6基于其他结构光纤的光镊探针结构及工作原理。(a)椭圆芯光纤光镊采用LP11模式 旋转酵母细胞[57];(b)多模干涉产生类贝塞尔光束原理示意图;制备全光纤类贝塞尔发生器及其几何参数图像[16]

    Figure 6.The structure and working principle of optical tweezers probe based on other core fiber structures. (a) Elliptical core optical fiber tweezers rotating yeast cells by using LP11mode laser[57]; (b) schematic diagram of the principle of Bessel-like beam generated by multimode interference; fabricated all-fiber Bessel beam generation and its geometric parameters[16]

    表 1特种芯光纤光镊微粒捕获能力汇总

    Table 1.Summary of particle capture abilities of hetero-core optical fiber tweezers

    光镊形式 光纤种类 微粒 折射率 微粒直径(µm) 功能 参考文献
    中空圆台探针 环形芯 聚苯乙烯小球 1.39、1.49、1.59 15、25、35 捕获、收集、输运 [13]
    二氧化硅微球
    集成探针
    环形芯 二氧化硅小球 2.2 6 捕获吸收性微粒 [14]
    对角反射镜探针 四芯 酵母菌细胞
    (椭球形)
    —— 7 捕获 [15]
    类贝塞尔发生器 空心 聚苯乙烯小球 1.55 10 多点位捕获 [16]
    金字塔棱锥探针 七芯 酵母菌细胞
    (椭球形)
    —— 6 捕获位置可调节轴向双向输运 [17]
    光学微手 四芯 酵母菌细胞
    (椭球形)
    —— 4-6 捕获旋转 [18]
    近场等离子激元 双芯 聚苯乙烯小球 1.49 0.01-5 二维捕获 [19]
    近场倏逝波 双芯 聚苯乙烯小球 1.59 2 二维捕获 [20]
    下载: 导出CSV

    表 2常用探针加工方法优缺点对比[21-24]

    Table 2.Comparison of probe processing methods[21-24]

    加工方法 优势 劣势
    研磨抛光法 可加工锥形、楔形、多边金字塔型,或抛光侧面实现反射;
    加工速度快,可重复性高
    对准精度要求高
    光纤蚀刻法 灵活性高、成本低、可重复性高,容易调整锥角 高危险腐蚀剂;表面相对粗糙;难以加工复杂结构
    聚焦离子束铣削 高精度加工,可加工不同角度棱锥或棱柱形 成本高;易受杂质离子干扰;不适于批量生产
    熔融拉锥 操作简便;成本低 可重复性低,不适用批量生产
    光纤端面镀膜 操作简单;能激发表面等离子体效应 易受杂质影响
    加压熔融拉锥 制备具有中空孔光纤探针 可重复性低,不适用批量生产
    下载: 导出CSV
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  • 收稿日期:2023-01-12
  • 修回日期:2023-02-20
  • 网络出版日期:2023-05-16

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